Cam Hilliard is, in addition to being the President's sixteen-year-old son, a chess prodigy. A year into President Hilliard's second term Cam inexplicably stops playing the game he loved and becomes withdrawn. The First Lady is convinced that the senior White House physician is wrong in diagnosing Cam's issue as a psychological one, and she demands that Dr. Lee Blackwood be brought on to provide a second opinion. Lee's opinion is dismissed, until Cam's spleen ruptures and it becomes obvious that something is horribly wrong. Lee informs the President and First Lady that to make a diagnosis they need to find other people with the same symptoms to conduct additional testing. From there, it's possible to identify the gene defects and correlate those to the missing enzymes. Only then can a diagnosis be made and treatment begun. For now, they must face the harsh reality that Cam's genes are producing a mutation that appears to be entirely new to science. As Lee delves into this medical mystery, he comes to believe Cam is not the first case of this presentation of an inborn error of metabolism. But when two young people Lee has found, each with exceptional gifts, are murdered, Cam's condition suddenly takes on a terrifyingly new dimension. Is someone out to murder the President's son? If so, why? As Lee searches for answers he will uncover unimaginable secrets and dark betrayals that breach the highest levels of security.